Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. The Position: Our client's Preclinical and Translational PKPD (PTPK) Department is looking for an exceptional laboratory-based contract scientist to work in the investigative PK/ ADME gr... more details
Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.
The Position:
Our client's Preclinical and Translational PKPD (PTPK) Department is looking for an exceptional laboratory-based contract scientist to work in the investigative PK/ADME group in South San Francisco. This position is to investigate the pharmacokinetics, biodistribution, metabolism, and the PKPD relationships of novel therapeutics in preclinical setting in support of early and late stage drug development. The candidate will be responsible for designing and implementing in-vitro and in-vivo studies that includes cell based in-vitro assay, radiolabeled tissue distribution studies, ADME studies to understand the properties of protein and nucleotide therapeutics. The candidate will interact and develop close partnerships across various functions including Research, Safety Assessment, PD Biomarker, Bioanalytical Assays, Clinical Sciences, Formulation and Regulatory. Additional component of the job will be sample/data analysis and presentation of results to cross-functional teams, department meetings, review committees, internal/external conferences, and regulatory agencies.
Job Responsibilities:
Design and implement in-vitro and in-vivo studies to address ADME questions of protein and nucleotide therapeutic. Writing and submitting protocol to cross functional team for review.
Carry out sample analysis (including tissue processing) by using different analytical methods.
Characterize and identify possible biotransformation products from protein and nucleotide therapeutic in different biological matrices.
Interpret data and communicate results in department meeting and project team meeting.
Prepare presentation and report for conferences, manuscripts and regulatory documents.
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