Job Abstract

Senior Scientist, Protein Engineering and Novel Modalities, Biologics Engineering, Oncology R&D

Are you a highly motivated scientist with a passion for innovative technology and biology? We are seeking to recruit someone like you to enhance our multispecific antibody-based platform technology efforts. Biologics Engineering is responsible for the discovery, design, engineering, and optimization of next-generation biologics to create biological drug candidates for all key therapeutic areas. Join us in our mission to push the boundaries of science to deliver life-changing medicines to patients!

As a Senior Scientist, you will lead collaborative workstreams with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects and drive technological innovations. You will conceive, design, and execute the engineering of innovative multispecific antibodies with improved selectivity and developability. Your role will also involve the biochemical, biophysical, and functional characterization of antibodies and multispecific modalities. You will also prepare, analyze, and present data internally and externally.

• PhD + 0-3 years’ of experience in Chemical or Biological Engineering, Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field with experience in protein engineering and/or bispecific antibody technologies
• Extensive hands-on experience in molecular biology and antibody/protein engineering
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines
• Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs
• Comprehensive experience in tissue culture techniques and functional cell-based assay development
• Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset

• Understanding of protein and antibody structure-function relationships
• Experience in engineering antibodies with improved properties (e.g., affinity, solubility, and other attributes related to developability)
• Experience with bispecific therapeutics, e.g. T-cell engagers, ADCs, checkpoint inhibitors
• Background in antibody discovery using one of several display-based technologies
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Are you ready to be dedicated to following the science? Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion and determination we are paving the way to change the practice of medicine in Oncology. Apply now!

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