Job Abstract

Senior Scientist - Integrated Bioanalysis – Proteomics

Bold Disruptors. Push the boundaries of science. Fearlessly break new ground.

Are you ready to work at the cutting-edge, where scientific innovations and an entrepreneurial spirit are the norm? We’re looking for dynamic thought leaders with curious minds, who are comfortable taking smart risks and constantly challenging the boundaries of science all the while learning and developing core skills and experiences.

What we do

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide.

Why we love it

The future is bright at AstraZeneca as we bring ground breaking therapies to complex disease to patients with critical needs. Scientific innovations are at the core of what we do across our industry leading portfolio which drive exciting opportunities and varied work. We’re on an exciting journey to pioneer the future of healthcare!

The role

As part of the Integrated Bioanalysis (iBA) Global Team, you will be responsible for advancing the utilisation and application of arrange of -omic technics with a specific focus on using mass spectrometry applications such as proteomics, metabolomics and lipidomic applications in discovery and early development.  The ideal candidate will have extensive technical expertise in developing assays and interpreting -omics for application such as pathways analysis, biomarker discovery and safety risk assessment characterization.  You will be responsible for assay development, optimization, qualification, execution, and transfer of high complexity assays using state-of-art instrumentation to support pre-clinical and clinical studies. You will also contribute to tech-transfer to established CRO partners and maybe called upon to review data to ensure assay are fit for purpose including troubleshooting and data analysis. You will be expected to provide scientific leadership to junior staff and to develop strong intra and inter-departmental collaborations.  You will be expected to contribute to the development of advanced bioanalytical techniques across all aspect of AZ portfolio within Oncology and Biopharma.  Working with a dynamic team in a matrixed environment you will need to manage stakeholder expectations, input to project strategy and delivery while being the main interface with experienced and highly skilled bioanalytical scientist colleagues or our partnered labs. You will have the opportunity to have an immediate and lasting impact to our diverse pipeline.

The iBA group within Clinical Pharmacology and Safety Sciences provides broad discovery, preclinical, and clinical support including life cycle management across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines.

What you’ll do

You will be located at one of our research hubs (Gaithersburg MD) where you will work alongside a team of experienced bioanalytical scientists supporting a projects across our portfolio.  You will also be working closely with discovery scientists across CPSS and partner line to maximise internal knowledge exchange and collaboration.   You will need to use your experience and proven track record of experimental design to support delivery of robust bioanalytical data.  You will also be called upon to interpret data and provide scientific insight.  As a Subject Matter Expert, you will be responsible for enhancing the iBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

The successful candidate will work closely with AstraZeneca laboratory groups within iBA and our vendor partners to ensure appropriate -omics methods are established, and we foster an environment of scientific. knowledge exchange. They will also interact with stakeholders and cross functional project teams.

Education/Experience required:

• PhD in analytical chemistry, biochemistry , genomics molecular biology  or related discipline with at least 2+ years of post-PhD experience

Essential for the role:

• Proven experience as a Subject Matter Expert in an array of proteomics techniques including the development broad spectrum and targeted proteomics strategies.
• Experience in both hypothesis generation and targeted analyses approached to using proteomics to resolve to perform pathway analysis or biomarker strategies.
• Design, execute, and troubleshoot technical challenges as they arise to ensure data is generated in a fit-for-purpose manner.
• Able to evaluate and interpret complex data sets.
• You will also be called upon to contextualize and interprets data for use in key project decisions.
• Employ a metabolomic/proteomics discovery platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.
• Experience using a broad array of proteomics platforms including but not limited to high resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments and ligand binding based technology platforms.
• Hands-on experience with chromatographic separation, characterization, and quantification of various analytes by LCMS or protein array platforms.
• Excellent organizational, documentation and technical writing skills
• Proficiency with mass spectrometry and other protein array software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
• Contribute to project technical teams to ensure effective communication and interpretation of data.
• Collaborate effectively to ensure productive interactions with all stakeholder groups.
• Foster advance technical applications to ensure data quality.
• Demonstrate strong accountability, organizational and interpersonal skills, and apply scientific and technical experience.
• Ensure high-quality, timely documentation in electronic laboratory notebooks and technical reports which support regulatory filings.
• Present data/ strategy to scientists and management in internally.
• Other duties as assigned. Interpretation of integrated and complicated datasets
• Ability to handle multiple projects and / or tasks concurrently in a fast-paced environment
• Ability to develop, coach and mentor
• Background in pharmaceutical clinical trial research
• Proven publication and presentation record
• Exceptional verbal and written communication skills

Desirable for the role:

• Experience with a broard array of multi-omic techniques including but not limited to RNA seq, cell- painting or genomics applications.
• Experience across a range of technology platforms including but not limited to LBA, Wester-blot, and PCR.
• Experienced in regulated bioanalysis for a range of drug modalities.

Date Posted

Closing Date