Job Abstract

Job Description/Qualifications:

Applications are sought for a full-time Assistant Project Scientist position. The successful candidate will serve as laboratory manager, organizing a series of projects, and working as part of an interdisciplinary research team in the laboratory of Dr. Stanley Nelson Lab in the UCLA Department of Human Genetics. The focus of the Nelson Lab is on understanding the genetic and molecular underpinnings of Duchenne Muscular dystrophy and developing methods for the solution of undiagnosed and likely genetic rare diseases. The Nelson lab leverages whole genome and exon sequencing, bulk RNAseq, and single cell/nuclei RNAseq experiment to investigate a wide array of biological questions related to Duchenne disease pathology. In addition to studying disease pathology, the Nelson lab to also leveraging these technologies to investigate physiological responses to gene therapies for the treatment of Duchenne muscular dystrophy

To address these questions, the Nelson lab is implementing a large scale combination of single cell/nuclei RNAseq, TCR/BCR clonotyping, spatial transcriptomics experiments. The ideal candidate will have extensive experience in cell and molecular biology and a good understanding of recent developments in single cell/single nuclei data generation, troubleshooting, and a strong team mindset to work collaboratively with geneticists, immunologists, and physicians to design, implement, improve, and analyze such experiments.

A successful candidate(s) will have the following qualifications:

• PhD in a Genetics or Cell Biology related discipline
• At least 2 years post graduate fellowship or experience in cell or molecular biology or genomics
• Ability to work in a collaborative interdisciplinary environment and experience in establishing new methods and approaches
• Experience generating single cell/nuclei RNAseq data
• Experience with sequencing, cloning, cell culture, DNA/RNA/Protein purification
• Experience with standard molecular and epigenetic methods
• Experience with laboratory management including ordering and safety compliance
• Experience with collect material from biopsies and inventory of the patients.
• Experience with laboratory equipment, supplies, and data analysis tools including inspecting, maintaining, and/or troubleshooting
• Prefer Experience studying Duchenne muscular dystrophy and/or skeletal muscle biology
• Experience drafting manuscripts, generating figures, and preparing text for grant applications in English.
• Desire to conduct cutting-edge developmental, genomics, molecular and cell biology research

To apply please upload a cover letter, curriculum vitae, Statement of Research, Statement of Diversity, and provide names and contact information for 3 references. Start date is flexible.

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Required Documents (CV, Cover Letter, References)
• Cover Letter
• CV
• 3 Reference Contact Only
• Statement of Research
• Statement of Diversity

Basic Qualifications:
• Ph.D. + 2Y post graduate scientific experience

Additional Qualifications:
• Experience with cell and nuclei harvest from archived muscle biopsies
• Familiarity with common bioinformatics tools for single cell analysis
• Familiarity with generating bulk RNAseq data
• Experience working with publicly available databases and repositories
• Experience with laboratory management
• Excellent oral and written communication skills
• Familiarity with cell culture
• Ability to manage large number of projects in parallel

Preferred Qualifications:
• First-author publication in relevant field
• Experience in muscle biology
• Experience in human genetics

PhD in related field + 2 years postdoc experience

• Experience with cell and nuclei harvest from archived muscle biopsies
• Familiarity with common bioinformatics tools for single cell analysis
• Familiarity with generating bulk RNAseq data
• Experience working with publicly available databases and repositories
• Experience with laboratory management
• Excellent oral and written communication skills
• Familiarity with cell culture
• Ability to manage large number of projects in parallel

• First-author publication in relevant field
• Experience in muscle biology
• Experience in human genetics

• 3-5 required (contact information only)

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

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