Job Abstract

Associate Director, Clinical Proteomics, Translational Medicine

Gaithersburg, MD

Do you have expertise in, and passion for, targeted mass spectrometry and clinical proteomics? Would you like to apply your expertise to impact the clinical development of oncology drugs with innovative biomarkers in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca’s Clinical Proteomics team, Gaithersburg, MD, is the place for you!

What you’ll do

AstraZeneca is seeking a scientist to support Translational Medicine efforts in Oncology as a member of the Clinical Proteomics team located in Gaithersburg, MD. The scientist should have experience in mass spectrometry-based proteomics. They will develop and carry out translational studies involving biomarker quantitation from clinical samples (e.g., tumor biopsies) to accelerate clinical development of AZ’s oncology drugs. This position requires an individual with outstanding technical skills and scientific experience as well as excellent communication and collaborative skills. The individual must thrive working in a fast-paced clinical and product development organization to translate fundamental insights using proteomics into targeted therapeutics and biomarker hypotheses that can be tested in clinical trials. The successful candidate is expected to drive the publication of proteomics data in top-tier scientific journals.

• Develop, validate and implement targeted MS-based proteomics technologies for clinical biomarker studies.
• Process clinical samples (e.g., FFPE tissue, plasma) for translational and clinical studies according to SOPs.
• Responsible for developing assays to generate high-quality PRM data for clinical studies, and collaborate with bioinformatics teams to demonstrate clinical utilities of protein biomarkers.
• Operate state-of-the-art LC-MS instruments, and ensure high-quality data generation by applying strict QC and routine maintenance. Stay current with the latest technologies to improve the protocols.
• Analyze data, summarize results, and present key results at functional reviews and project reviews.

Essential for the role

• PhD in bioanalytical chemistry or related field with 5+ years post-doctoral experience in mass spectrometry-based proteomics.
• Strong publication record in proteomics, with multiple first-author publications in high quality journals.
• In-depth understanding of various quantitation technologies including PRM and DIA, and their clinical applications.
• Experience in targeted proteomics and PRM/SRM assay development for oncology biomarkers.
• Strong theoretical understanding of protein biochemistry and practical knowledge of bottom-up proteomics.
• Experience in processing human tissue samples for proteomics analysis.
• Solid understanding of separation chemistry for protein/peptide analysis with experience of nano-flow HPLC.
• Extensive experience in instrumentation, trouble shooting, QC, standardization for proteomics workflow and pipeline development.
• Coding skills (R, Python) for data analysis, and ability to use/evaluate open-source software packages for processing mass spectrometry data.
• Experience in working independently and collaboratively in a matrixed environment with some experience in project management.
• Strong written and oral communication skills.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Ready to make a meaningful difference? Apply now and join us in our mission to eliminate cancer as a cause of death!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: July 21, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted

Closing Date