Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what sc... more details
Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
About AstraZeneca in Gaithersburg, MD:
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most ground breaking technology and lab spaces, all crafted to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.
In Purification Process Sciences in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.? We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
Main Duties & Responsibilities:
In this role, the Associate Scientist will need to develop and characterize downstream processes for the manufacture of biopharmaceuticals (monoclonal antibodies and other proteins) in late stage clinical development through commercial launch. He / She will be responsible for a portion of a purification development project which will require the scientist to make observations, analyze data and interpret results. In addition, they will also:
o Maintain accurate records of experimental results, review, analysis, and interpretation of experimental data.
o Make periodic presentations in group meetings, project team meetings, and in one-on-one situations.
o Prepare/review development reports, tech transfer and process validation documents, regulatory submissions.
o Support technology transfer to Clinical/Commercial Manufacturing facilities.
o Support troubleshooting and resolution of deviations in GMP manufacturing processes.
o Evaluate of new technologies to facilitate process development.
Education & Experience Requirements:
Bachelor's or Master's Degree in Biochemistry, Chemical Engineering, or related field.
BS/MS with 0+ years of experience required
o Proficiency in protein purification principles and methods including (but not limited to) different modes of chromatography, viral removal/inactivation steps and filtration.
o Highly team-oriented, energetic, critical thinker, organized, capable of significant multitasking with excellent oral and written communication skills
o Knowledge of basic protein chemistry; protein and analytical chemistry, process robustness concepts and process scale-up
o Working knowledge of good laboratory practices
o Knowledge of purification process design
o Knowledge of basic analytical techniques for protein products (HPLC analysis, protein quantification methods, electrophoresis; etc.)
o Working knowledge of AKTA systems/software and JMP software
o Statistical design of experiments (DOE)
o Process scale-up and technology transfer
o cGMP manufacturing principles and environments
o Process validation
o Familiarity with risk assessments and Regulatory submissions (especially BLA)
o Mechanistic modeling of chromatography and other unit operations
o Purification of protein-based therapeutics other than antibodies (eg. conjugates, bispecifics, fusion proteins or products produced by microbial systems)
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
Where can I find out more?
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
Date Posted
22-May-2024
Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.