| Overview | New Jersey’s academic health center, Rutgers Biomedical and Health Sciences (RBHS) takes an integrated approach to educating students, providing clinical care, and conducting research, all with the goal of improving human health. Aligned with Rutgers University–New Brunswick and collaborating university wide, RBHS includes eight schools, a behavioral health network, and five centers and institutes that focus on cancer treatment and research, neuroscience, advanced biotechnology and medicine, environmental and occupational health, and health care policy and aging research.
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| Posting Summary | Rutgers, The State University of New Jersey, is seeking a Research Scientist II for NJMS- Medicine- infectious diseases. Under the direction of the Principal Investigator, the Research Scientist II will be involved in two research programs designed to: i) test the hypothesis that Mycobacterium tuberculosis (Mtb) exploits the immunosuppressive indolamine 2,3-dioxygenase (IDO)-mediated tryptophan catabolic pathway to evade antituberculosis (TB) immunity in order to persist in an infected host; and ii) elucidate how B cells and antibodies (Ab) shape the immune responses to the tubercle bacillus using murine experimental TB models and samples from human cohorts. The IDO study should generate useful information regarding the mechanisms underlying Mtb persistence. The B cell/Ab study will inform about how the B cell and humoral immunity regulate anti-TB responses and may provide targets for optimizing anti-TB activity and augment vaccine immunogenicity. A combination of genetic, biochemical, and immunological approaches, together with various murine experimental tuberculosis models, will be employed for these studies.
Among the key duties of this position are the following: - Characterizes the mechanisms by which Mtb regulates anti-TB immunity using in vitro and in vivo systems.
- Conducts experiments to elucidate how B cells and Ab modulate the immune response of an Mtbinfected host and influence the infection and disease outcome, using both mouse TB models and human systems.
- Generation of cell- and IDO isoform-specific knockout mouse strains.
- Conducts experiments designed to study interaction of antigen presenting cells with T cells using in vitro model systems.
- Determines the role of IDO in regulating the immune response to anti-Mtb vaccines using mouse immunization-challenge models
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