Dr. England’s research laboratory ( is developing small molecules to control the activity of nuclear receptors, a class of ligand-regulated transcription factors that play critical roles in human health and disease. The Biologist will characterize the effects of small molecules on the activity of nuclear receptors using cellular assays, including luciferase reporter assays and gene transcription assays (R - Tq. PCR), work up and analyze data (including statistical analyses). Other aspects of the... more details
Dr. England’s research laboratory (https://pharm.ucsf.edu/england) is developing small molecules to control the activity of nuclear receptors, a class of ligand-regulated transcription factors that play critical roles in human health and disease. The Biologist will characterize the effects of small molecules on the activity of nuclear receptors using cellular assays, including luciferase reporter assays and gene transcription assays (RTqPCR), work up and analyze data (including statistical analyses).
Other aspects of the project may involve developing DNA constructs to explore various aspects of nuclear receptor functioning in cells and characterizing ligand effects on the localization and trafficking of nuclear receptors using appropriate microscopic imaging tools and techniques. Must have prior research laboratory experience, be proficient in aseptic techniques, and be willing/able to design and troubleshoot experiments.
To see the salary range for this position (we recommend that you make a note of the job code and use that to look up): TCS Non-Academic Titles Search (ucop.edu)
Please note: The compensation ranges listed online for roles not covered by a bargaining unit agreement are very wide, however a job offer will typically fall in the range of 80% - 120% of the established mid-point. An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role.
For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.
To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html
PhD in cellular and molecular biology or related field
BA/BS in related science including one year of recent/directly related work experience utilizing the techniques/methods required by the position; and/or equivalent experience/training
Hands-on research experience working with cultured and/or primary cells and carrying out cellular assays in a research laboratory (college laboratory courses are not sufficient)
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