The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a Blast Induced Neurotrauma Principal Investigator to support our government customer located in Silver Spring, MD.
DESCRIPTION OF RESPONSIBILITIES:
- Leads research and development activities.
- Relies on extensive experience and judgment to plan and accomplish goals.
- May provide consultation on complex projects. A wide degree of creativity and latitude is expected.
- Provide planning preclinical research experiments accounting for the impact of hemorrhagic shock and traumatic brain injury.
- Determine what pathological characteristics are measurable in the acute, subacute, and chronic periods following brain injury.
- Provide scientific and technical support for the research, development, and efficacy evaluation of neuro-protection/neuro-restoration therapies with the ability to fully characterize head injury models defining the temporal profile of histopathology, neurobehavioral (motor/cognitive) dysfunction, molecular (biomarkers/bioenergetics) and electrophysiological (EEG) changes following a "single" or repetitive injury to the brain such as:
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- Penetrating Ballistic-like Brain Injury (PBBI) Research
- Projectile Concussive Impact (PCI) Brain Injury Research
- Polytrauma Neurotherapeutic Resuscitation Research using an Aortic Tourniquet
- Neural Stem Cell Research
- TBI Neuroprotection and Neuro-restoration Research
- Non-convulsive Seizures Research
- Molecular Mechanisms, Biomarkers Identification and Therapeutic Intervention for TBI Research
- Conduct and analyze brain trauma neuroprotection, neuro-restoration, and neurotherapeutic research, including therapeutic strategies, blood-brain barrier (BBB) permeability, immune-inflammatory responses, biomarkers, pathology and sequalae following trauma as well as the molecular and cellular mechanisms of brain injury.
- Use models to validate and characterize scaled experimental blast exposure conditions and assess outcomes relevant to blast-injured Warfighters to define the biomechanical and neurobiological underpinnings of blast traumatic brain injury (TBI) and establish effective countermeasures.
- Characterize individual operator blast exposures in a variety of training environments to identify the effects of blast overpressure exposures on cognitive performance, brain and blood biomarkers, and symptom reporting.
- Conduct all aspects of scientific research experiments according to individual reviewed protocols.
- Perform research studies to include writing protocols, executing protocols, analyzing data, and writing manuscripts.
- Communicate and correspond with lead investigator(s) regarding experimental procedures, study progress, concerns about the study, and changes in procedure on a regular and ongoing basis.
- Perform routine and specialized behavior tests and procedures on animals and humans.
- Design and coordinate experiments, provide guidance and assistance to research staff and collaborators, and answer questions about experimental objectives and techniques to be used to fulfill these objectives.
- Recommend equipment acquisitions appropriate for experimental procedures and maintain laboratory inventory of chemical reagents and surgical supplies required for these tasks.
- Compile, analyze, and interpret data.
- Prepare or contribute to the summary of experimental findings for presentation at laboratory discussions, at scientific meetings, in reports, and in scientific journals.
- Assist in the preparing and submitting research proposals to funding agencies along with reports and briefings required for funded research.
- Identify and quantify pathophysiological mediators in biological fluids and tissue extracts as part of an overall effort to recognize biomarkers to non-invasively categorize blast TBI severity and etiology.
- Evaluate neuroprotective pharmacological therapies using neurobehavioral, histopathological, and neurochemical outcome measures.
- Assess the cellular basis for blast-induced brain dysfunction and neuronal injury.
- Routinely review the scientific literature for reports relevant to ongoing research in blast TBI and polytrauma.
- As needed, develop laboratory techniques, and assays; instruct others to correctly use these procedures, and record them as a laboratory Standing Operating Procedure (SOP).
- Other duties as assigned by Supervisor.
REQUIRED DEGREE/EDUCATION/CERTIFICATION:
- Doctorate degree and post-doctoral training in physiology and/or neuroscience.
- A minimum of 8 years of experience in physiology and/or neuroscience.
REQUIRED SKILLS AND EXPERIENCE:
- Extensive hands-on experience in rodent surgery and physiological monitoring techniques related to bTBI.
- Demonstrated expertise in a variety of the field's concepts, practices, and procedures.
- Must have the ability to fully characterize head injury models defining the temporal profile of histopathology, neurobehavioral (motor/cognitive) dysfunction, molecular (biomarkers/bioenergetics) and electrophysiological (EEG) changes following a "single" or repetitive injury to the brain such as:
-
- Penetrating Ballistic-like Brain Injury (PBBI) Research
- Projectile Concussive Impact (PCI) Brain Injury Research
- Polytrauma Neurotherapeutic Resuscitation Research using an Aortic Tourniquet
- Neural Stem Cell Research
- TBI Neuroprotection and Neurorestoration Research
- Non-convulsive Seizures Research
- Molecular Mechanisms, Biomarkers Identification and Therapeutic Intervention for TBI Research
REQUIRED CITIZENSHIP AND CLEARANCE:
- Must be U.S. Citizen.
- Must hold a minimum DoD Clearance level of Public Trust, with ability to obtain Secret.
?The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees enjoy a 401K plan with company match; medical, dental, disability, and life insurance coverage; tuition reimbursement; paid time off; and 11 paid holidays.
We are an Equal Opportunity/Affirmative Action Employer. We are proud to state that we do not discriminate in employment decisions on the basis of race, color, religion, sex, pregnancy, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status. If you are a person with a disability and you need an accommodation during the application process, please click here to request accommodation. We E-Verify all employees.
The Alaka`ina Foundation Family of Companies (FOCs) is comprised of industry-recognized government service firms designated as Native Hawaiian Organization (NHO)-owned and 8(a) certified businesses. The Family of Companies (FOCs) includes Ke`aki Technologies, Laulima Government Solutions, Kupono Government Services, and Kapili Services, Po`okela Solutions, Kikaha Solutions, LLC, and Pololei Solutions, LLC. Alaka`ina Foundation activities principally benefit the youth of Hawaii through charitable efforts which includes providing innovative educational programs that combine leadership, science & technology, and environmental stewardship.
For additional information, please visit www.alakainafoundation.com
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