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| Posting Summary | Rutgers, The State University of New Jersey, is seeking a Postdoctoral Fellow for the department of Neuroscience & Cell Biology at the Robert Wood Johnson Medical School.
Applications are invited for motivated scholars with a strong background in lysosomal biology or cell biology to join the laboratory of Pingyue Pan at the Department of Neuroscience and Cell Biology in Rutgers University – Robert Wood Johnson Medical School. The primary research interest in the lab is to understand dopaminergic signaling and its dysregulation in Parkinson’s disease and substance use disorder. Currently, we are investigating the Synj1 gene, which is linked to multiple dopamine related illnesses, including Parkinsonism. In our recent study, we found altered lysosomal parameters and abnormal autolysosomal function in the Synj1 haploinsufficient mouse. Dysfunctional endolysosomal system is highly implicated in the pathogenesis of PD, however, it remains to be investigated whether and how PD associated Synj1 mutation influences the autolysosomal system leading to neurodegeneration. This question will be addressed using novel transgenic mouse models with dopamine neuron specific deletion of Synj1. We employ primary dopamine neuron cultures from transgenic mouse models combined with quantitative imaging, biochemical and behavioral analyses to understand these mechanisms. The position is funded by the NIH R01 grant and startup funds.
Among the key duties of this position are the following: - Design and lead the project as directed by the supervisor.
- Engages in frequent scientific communication with your supervisor/mentor.
- Perform cell culture, live cell imaging, molecular cloning, biochemical assays, brain pathology analysis, behavioral assessment, data analysis and presentation.
- Assist in maintenance of transgenic mice lines in the vivarium. This involves handling mice for breeding, tail snipping, ear marking and PCR-genotyping.
- Participate in the evaluation of the existing procedures, suggesting revisions and designing new procedures where necessary. Participate in the development of new protocols, procedures, and cell lines in the lab.
- Contribute to the development of performance standards, selection of methodology and instrumentation and coordination of the analytical, biochemical, physiology and instrumentation functions with the research areas to ensure conformance with the goals and objectives of the department. As required, assists in the implementation of the programs and projects in special areas of interest to the department.
- Maintain accurate records of laboratory notebooks and research activity.
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