Job Abstract

Job Title: Associate Director, Oncology Safety Science

Introduction to role:
Are you ready to make a significant impact in the world of oncology? We are seeking a highly motivated Associate Director to support the development of novel oncology medicines with a focus on T Cell Engagers for haem and solid tumor indications. This is your chance to be part of our Oncology R&D organization, where you will support investigative toxicology for project progression and drive our safety science forward to inform the design and selection of drug candidates with the “right safety” profile. 

Accountabilities:
As an integral member of our multi-disciplinary drug discovery teams, you will direct investigative toxicology strategies to predict, assess and mitigate target- and modality-related safety risks in discovery programs. You will apply investigational and mechanistic safety studies through in vitro experimental capabilities to predict clinical safety and inform decision-making in drug discovery and development programs. You will also contribute to early oncology project decision making, address specific concerns, and present findings to ensure that teams can make the right decisions regarding safety risks that facilitate timelines and regulatory submissions.

Essential Skills/Experience:
• PhD in immunology, cancer biology, cell biology, toxicology, pharmacology, or related field with experience preferably in industry or academic setting with a minimum of 3 years’ experience.
• A proven understanding of drug discovery and development, with a strong scientific track record with experience of independent research in industry, biotech, or academic setting, working with relevant T Cell Engagers.
• Experience with in vitro cellular biology/immunology assays applied to physiologically relevant human cellular models, flow cytometry, multiplex cytokine measurements, activation and cytotoxicity assays, micro-physiological systems, 3D organoids, membrane protein arrays, omics technologies, confocal imaging.
• Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers on biological systems with line of sight to human safety may be considered an advantage.
• The ability to build an understanding of biology around novel drug targets and pathways, develop testable hypotheses, and drive scientific learning.
• A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects.
• Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development within an industry setting.

Desirable Skills/Experience:
• Masters degree or equivalent qualification

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
At AstraZeneca's Biopharmaceuticals R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. 

Ready to embrace new and varied opportunities to develop and learn? This is the place to build a meaningful career as we push the boundaries of science to deliver life-changing medicines. Curious minds, we are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex disease.

Are you ready to be part of a team that makes a bigger impact on patients' lives? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. Apply today and join us in our mission to create a healthier world!

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