The Gu lab is interested in enhancing the efficacy of cancer immunotherapy by modulating cell-cell interactions. To achieve this goal, we integrate various cutting-edge experimental and computational approaches in the areas of functional genomics, single cell/spatial mutli-omics, data mining, machine learning, and mathematical modeling, among others. Current research directions of the lab include context-dependent regulation of cancer antigen presentation and novel mechanisms of cell-cell intera... more details
MISSION STATEMENT The mission of The University of Texas MD Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.
SUMMARY The Gu lab is interested in enhancing the efficacy of cancer immunotherapy by modulating cell-cell interactions. To achieve this goal, we integrate various cutting-edge experimental and computational approaches in the areas of functional genomics, single cell/spatial mutli-omics, data mining, machine learning, and mathematical modeling, among others. Current research directions of the lab include context-dependent regulation of cancer antigen presentation and novel mechanisms of cell-cell interaction. We have excellent track record in highly collaborative and interdisciplinary research in cancer biology, immunology, and computational biology, with major papers as follows: Leukemia biology: (Gu, Chan, Mohi et al., Blood, 2016; Gu et al., Leukemia, 2018) Cancer immunology: (Jiang, Gu, Pan et al., Nature Medicine, 2018; Gu, Wang, Hu et al., Genome Biology, 2020; Shi, Gu et al., Clinical Cancer Research, 2020; Gu, Zhang, Wang, Jiang et al., Cancer Discovery, 2021; Wang, Tokheim, Gu, Wang et al., Cell, 2021; Zeng, Gu et al., Cancer Immunology Research, 2022) Computational biology: (Gu et al., PNAS, 2021; Zeng, Gu et al., Science Advances, 2022). The primary purpose of the Research Scientist position is to carry out cancer research projects while following standard operating procedures for the laboratory.
JOB SPECIFIC COMPETENCIES
Supervision
Personnel: Oversees workflow and lab productivity; provide and receive feedback; ensure cultural continuity; lab specific on-boarding/orientation of new members; annual reviews of technical staff.
Scientific: Develop, modify, and improve SOPs; provide training on specific techniques and advice on experimental design to lab members.
Operational: Maintain and improve operational service; equipment service orders; safety compliances; facilities service requisitions; ensures lab compliance with MDACC and accredited agency mandatory regulations/trainings.
Financial: Coordinate with PI to monitor/plan budget; order requisitions; inventory maintenance; budget integrity; negotiate with vendors.
Research
Independently design experiments and interpret results.
Prioritize and manage multiple experiments in a timely and resource-effective manner.
Report research findings (oral and written) at internal, local, and national meetings.
Use in vitro and in vivo experimental systems along with functional genomic approaches to identify and characterize immune cell populations and/or immunomodulatory pathways.
Equipment, supply management & laboratory safety
Select and purchase new equipment in consultation with other professional staff and maintains technical equipment for the laboratory.
Manage inventory of biologics and replenishes them as needed.
Order materials for research studies as needed.
Assist PI to ensure correct practice of laboratory safety as required under institutional guidelines.
Education Required: Master's degree in one of the natural sciences or related field.
Education Preferred: PhD in biology, bioinformatics, computer science, or related areas.
Experience Required: Four years of experience in experimental or scientific work. With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
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