Overview | New Jersey’s academic health center, Rutgers Biomedical and Health Sciences (RBHS) takes an integrated approach to educating students, providing clinical care, and conducting research, all with the goal of improving human health. Aligned with Rutgers University–New Brunswick and collaborating university wide, RBHS includes eight schools, a behavioral health network, and five centers and institutes that focus on cancer treatment and research, neuroscience, advanced biotechnology and medicine, environmental and occupational health, and health care policy and aging research.
Our faculty are teachers, clinicians, and scientists with unparalleled experience who advance medical innovation and provide patient care informed by the latest research findings. We offer an outstanding education in medicine, dentistry, pharmacy, public health, nursing, biomedical research, and the full spectrum of allied health careers.
Our clinical and academic facilities are located throughout the state—at Rutgers University–New Brunswick, including Piscataway; and at locations in Newark, Scotch Plains, Somerset, Stratford, and other locations. Clinical partners include Robert Wood Johnson University Hospital in New Brunswick, Newark’s University Hospital in Newark, and other affiliates.
Through this community of healers, scientists, and scholars, Rutgers is equipped as never before to transform lives. |
Posting Summary | Rutgers, The State University of New Jersey, is seeking a Postdoctoral Fellow for the department of Pharmacology in the Center for Advanced Biotechnology and Medicine (CABM). The Valvezan lab studies how metabolic networks are coordinated to promote cell growth, and how to leverage that understanding to exploit metabolic dependencies in cancer. We recently discovered that the activity of the master metabolic regulator Mechanistic Target of Rapamycin Complex 1 (mTORC1), oscillates throughout the cell cycle with important functional consequences for cell growth and proliferation (https://www.biorxiv.org/content/10.1101/2024.02.06.579216v1). We seek a postdoctoral fellow to study how metabolism is differentially regulated throughout the cell cycle, and whether there are cell cycle phase-specific metabolic vulnerabilities that can be exploited in cancer.
We discovered a targetable metabolic vulnerability that is induced downstream of mTORC1 in cancer, and can be exploited using clinically approved therapeutics to selectively kill cancer cells that have uncontrolled mTORC1 activation (https://pubmed.ncbi.nlm.nih.gov/29056426/, https://pubmed.ncbi.nlm.nih.gov/32271165/). We seek a Postdoctoral Fellow to determine the full translational potential of this potent vulnerability in human cancers.
The Postdoctoral Fellow will work at the interface of basic and translational science, combining genetic, pharmacological and molecular biology/biochemistry approaches with the latest metabolomics, metabolic flux analysis, and expression profiling assays in cultured cells and mouse tumor models to gain a comprehensive understanding of how signaling pathways remodel cellular metabolism and how to leverage these insights for therapeutic benefit. For more information, including detailed project descriptions, please contact Dr. Alexander Valvezan at valvezan@cabm.rutgers.edu and visit the lab website: https://sites.rutgers.edu/valvezan-lab/research/
Among the key duties of this position are the following:
- Carries out an independent research project studying signaling and/or metabolism in cell growth and cancer.
- Keeps detailed records of procedures and experiments. Compiles data and present findings.
- Prepares scientific manuscripts for publication and contributes to the preparation of research grant and fellowship applications.
- Works independently as well as collaboratively, with a strong work ethic and attention to detail.
- Cell cycle phase-specific control of cellular metabolism in health and disease.
- Exploiting metabolic vulnerabilities in cancer.
|