Plan, execute and analyze in vivo pharmacology studies. Characterize new in vivo mouse models, including syngeneic genetically engineered and orthotopic mouse models to study biologic mechanisms and support exploration of novel therapies. Conduct in vivo studies to evaluate and establish efficacy, PK/ PD relationship, combination strategy, biomarker identification and analysis. Perform ancillary in vitro and ex vivo assays to characterize effects of experimental medicines that may include Wester... more details
As a member of a team of scientists in our In Vivo Pharmacology Cancer Cell Biology Group, you will play a lead role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.
You will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to cancer cell signaling, epigenetic and oncogenic networks. You will characterize and develop large and small molecules in close collaboration with partner lines as an integral member of the drug discovery teams. You will employ and develop cutting edge in vivo cancer models and provide technical and scientific expertise in in vivo Pharmacology across Oncology Research and Development to enable target identification, validation, prioritization, and efficient drug discovery.
ROLE RESPONSIBILITIES
Plan, execute and analyze in vivo pharmacology studies.
Characterize new in vivo mouse models, including syngeneic genetically engineered and orthotopic mouse models to study biologic mechanisms and support exploration of novel therapies.
Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Perform ancillary in vitro and ex vivo assays to characterize effects of experimental medicines that may include Western Blot, scRNAseq or other assays as needed.
Quality documentation and interpretation of experimental results
Presentation of results within a multidisciplinary team environment.
Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards.
BASIC QUALIFICATIONS
Bachelor’s degree in Biology/Tumor Biology/Oncology or similar discipline
6+ years relevant in-vivo experience
Experience with animal models of human cancers.
Hands on in vivo skills (IV, PO, SC, IP dosing), blood/tissue collection
Experience following novel scientific or technological developments, and implementing them in the laboratory.
Excellent written and oral communication and presentation skills
Experience integrating biological concepts into experimental design
PREFERRED QUALIFICATIONS
Ex vivo skills such as Western blot
Experience with GraphPad Prism and/or Studylog
Industry experience preferred
Current knowledge of Oncology research, drug discovery and development
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses)
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Relocation support available
Work Location Assignment: Flexible
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
