Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what sc... more details
Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
About AstraZeneca in Gaithersburg, MD:
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most ground breaking technology and lab spaces, all crafted to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.
Summary of the group:
The Biopharmaceutical Development group is a multi-disciplinary scientific function providing expertise in Process/Analytical/Formulation/Devices Development and Characterization with integrated Bioprocess Engineering, Clinical Manufacturing, and Supply Chain and Logistics operations. The group is also responsible for transferring the processes to different commercial sites in and outside the AstraZeneca organization. BPD group is present in multiple sites including Gaithersburg, MD, and Cambridge UK.
The Purification Process Sciences Group is accountable for purification and conjugation process development of complex biopharmaceuticals including proteins, monoclonal antibodies, antibody-drug conjugates, nucleic-acid based modalities, and vaccines. This group assists in the scale up and technical transfer of processes to different clinical and commercial sites and supports manufacturing deviations and regulatory submissions as needed.
Job Description
The Associate Scientist in this position is encouraged to have a thorough understanding of purification techniques and principles for large biologicals including liquid chromatography, normal and cross flow filtration. The Associate Scientist s expected to design, develop, and execute purification processes to meet early-stage process development objectives and timelines. The candidate is expected to assist in the preparation of regulatory documents.
- Develop and characterize purification and conjugation processes for the manufacture of complex biopharmaceuticals including monoclonal antibodies, antibody-drug conjugates, RNA, and vaccines.
- Documents experiments, data, technical reports, and findings electronically in an accessible manner
- Presents findings, progress, and data proactively and regularly in group and department meetings.
- Functions with limited supervision and is encouraged to work independently on a day-to-day basis. Expectation for independence will increase with time and experience in the position.
Education & Experience Requirements:
Associate Scientist:
Requires a Bachelor’s degree with 0+ years of relevant industrial experience or Master’s degree in Biochemistry, Biology, Chemical/Biochemical Engineering, or related field.
Required Skills:
- Must have basic knowledge of protein chemistry and protein purification principles.
- Must have basic knowledge of protein analytical techniques including concentration measurements and purity analysis by SDS-PAGE, HPLC or similar.
- Has the ability to learn new technologies fast and identify new scientific concepts to advance purification process development.
- Must be highly self-motivated and have the ability to own and drive projects to success.
- Must have excellent teamwork, communication, and time management skills.
- Must be proficient in Microsoft Office (or related) programs.
Desired Skills:
- Hands on protein purification experience using AKTA systems and software or similar.
- Hands on filtrations experience, including depth, normal and tangential flow filtrations.
- Experience with monoclonal antibody purification process development considered a plus.
- Experience with antibody drug conjugation processes considered a plus.
- Experience with RNA and viral vector purification considered a plus.
- Experience in UV-Vis and fluorescence-based assays for oligonucleotide analysis a plus
- Knowledge of design of experiment (DOE) methodologies and data analysis using statistical analysis software such as JMP or similar considered a plus.
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what’s next!
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
Where can I find out more?
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
Date Posted
23-May-2024
Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.