Include:You will be an expert in your area and play an active role in implementing and performing scientific research and development strategy within the metabolism department, enabling the prosecution of a rapidly growing portfolio of drug projects across multiple modalities. Be a "hands-on" expert in developing new in vivo models and methodologies with an enthusiasm for laboratory work and scientific curiosity. Play a leading role in assay development and optimization of screening cascades in ... more details
Are you an expert in in vivo pharmacology within the metabolic disease research area? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic (CVRM) diseases!
Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a high caliber Associate Principal Scientist to join the in vivo metabolism bioscience team within Research and Early Development CVRM. The position is placed at AstraZeneca’s dynamic R&D site in Gaithersburg, US.
CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM Metabolism Bioscience department has a dynamic environment that fosters collaboration and innovation. We are a team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients suffering from diabetes, obesity and liver diseases.
What you’ll do:
This is both a lab-based and project leadership role where you will provide scientific leadership through developing and leading scientific and technical capabilities required for progressing drug discovery projects within the metabolic disease area. You will provide key experimental data supporting multi-disciplinary project teams in Cambridge, Gothenburg and Gaithersburg.
Responsibilities include:
- You will be an expert in your area and play an active role in implementing and performing scientific research and development strategy within the metabolism department, enabling the prosecution of a rapidly growing portfolio of drug projects across multiple modalities.
- Be a "hands-on" expert in developing new in vivo models and methodologies with an enthusiasm for laboratory work and scientific curiosity. Play a leading role in assay development and optimization of screening cascades in relevant in vivo disease models, being responsible for design, execution, analysis and communication of in vivo studies.
- Act as lead biologist and project leader for drug discovery projects.
- Act as a champion for novel approaches for drug discovery in metabolic disease area, promoting scientific debate within CVRM Research and playing a leading role in the selection and validation of new targets.
- Raise the scientific profile of CVRM both within AstraZeneca and externally through publications and presentations, as well as initiating or participating in external collaborations.
Essential for the role
- PhD in life sciences with relevant postdoctoral experience.
- 5+ years industry experience with strong background in metabolic disease research areas such as diabetes, obesity, dyslipidemia and/or MASH.
- Proven expertise in in vivo pharmacology and physiology and hands-on skills to develop models supporting AstraZeneca’s discovery programs with expertise in surgical procedures; as well as drug metabolism and pharmacokinetics.
- Strong interest in problem solving through design and execution of complex in vivo mechanistic studies and robust expertise in data analysis, interpretation and data quality control.
- Evidence of scientific leadership recognised by publication record in leading peer reviewed journals, with enthusiasm to maintain a high external scientific profile through publication and conference presentations.
- Excellent organisational, time management, communication and interpersonal skills.
Desirable for the role
- Experience working within drug discovery projects in pharmaceutical or biotech environment with proven expertise in leading drug discovery projects
- Significant experience of numerous in vitro and ex vivo technologies for assessing signaling endpoints for multiple target classes (qPCR, Western Blots, ELISA).
- Experience of writing ethical applications and managing IACUC protocols relevant to in vivo models/studies
- Strong ability in leading several simultaneous projects/tasks
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.
We are eager to know more about you. If you are interested to know more about us, apply now!
Date Posted
15-May-2024
Closing Date
14-Jun-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
