As an integral member of this dynamic team, you will be:Producing membrane proteins in insect and mammalian expression systems. Performing biochemical/ biophysical assays as necessary to ensure protein activity/ folding. Assisting in structure determination of multiprotein complexes by cryo-EM. Supporting crystallization screening and optimize conditions of co-crystallization of protein-ligand complexes to produce high-quality crystals for X-ray diffraction. Who You Are:PhD in structural biology... more details
Senior Scientist, Structural Biology
We advance science so that we all have more time with the people we love.
Carmot Therapeutics, Inc., is a clinical-stage biotechnology company applying its proprietary drug discovery platform, Chemotype Evolution (CE), to discover and develop disease-modifying therapies in metabolic diseases and cancer. This position requires cross functional work within our biology, pharmacology, and chemistry teams. Our environment is exciting and fast paced, requiring you to be excellent at multitasking and easily adaptable to meet evolving goals. At Carmot we value diverse perspectives and encourage our scientists to contribute at multiple levels within the company, including strategic development.
The Opportunity:
As an integral member of this dynamic team, you will be:
Producing membrane proteins in insect and mammalian expression systems.
Performing biochemical/ biophysical assays as necessary to ensure protein activity/ folding.
Assisting in structure determination of multiprotein complexes by cryo-EM.
Supporting crystallization screening and optimize conditions of co-crystallization of protein-ligand complexes to produce high-quality crystals for X-ray diffraction.
Who You Are:
PhD in structural biology, biophysics, biochemistry or related discipline with 0-3 years in the following: Insect (Sf9, Tni) and mammalian (HEK293, CHO) cell culture. Production of baculoviruses/ bacmam viruses including viral titer determination. Membrane protein expression in insect and mammalian cells. Protein purification using Akta systems, affinity and size-exclusion chromatography.
Team Collaboration Skills: Ability to work in a diverse team setting.
Communication and Organization: Excellent communication, interpersonal and organizational skills, including keeping clear and consistent lab notes.
Preferred Qualifications
In addition to the above required qualifications, candidates with the following will have preferences.
Relocation benefits are not available for this job posting.
The expected salary range for this position based on the primary location of Berkley, California is $119,600-$222,200 Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
